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Table 1 Non-synonymous mutations in the rpoB gene conferring rifampicin resistance

From: Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress

High temperature adapted clones Nucleotide change Amino acid change Mutation change Codon change Phenotype (MIC in Rifampicin) Level of rifampicin resistance
56 ATC → TTC Ile (I) → Phe (F) A1714T I572F 800 μg/mL VERY HIGH
61 ATC → TTC Ile (I) → Phe (F) A1714T I572F 800 μg/mL  
27 ATC → CTC Ile (I) → Leu (L) A1714C I572L 100 μg/mL HIGH
35 ATC → CTC Ile (I) → Leu (L) A1714C I572L 100 μg/mL
92 ATC → CTC Ile (I) → Leu (L) A1714C I572L 100 μg/mL
97 ATC → CTC Ile (I) → Leu (L) A1714C I572L 100 μg/mL
142 ATC → CTC Ile (I) → Leu (L) A1714C I572L 100 μg/mL  
4 ATC → AAC Ile (I) → Asn (N) T1715A I572N 50 μg/mL INTERMEDIATE
43 ATC → AAC Ile (I) → Asn (N) T1715A I572N 25 μg/mL
77 ATC → AAC Ile (I) → Asn (N) T1715A I572N 25 μg/mL
112 ATC → AAC Ile (I) → Asn (N) T1715A I572N 50 μg/mL
131 ATC → AAC Ile (I) → Asn (N) T1715A I572N 25 μg/mL
59 CGT → CTT Arg (R) → Leu (L) G428T R143L 25 μg/mL