Figure 4

Conserved linkage of PPP1R2P2, PPP1R2P10/4, PPP1R2P5 and PPP1R2P6. PPP1R2P2, PPP1R2P10/4, PPP1R2P5 and PPP1R2P6 location in terms of chromosome and flanking genes is presented concerning each species where were found, to show the conserved linkage in these pseudogenes. Divergence time is shown on the left. The nucleotide number flanking the pseudogenes is related to the parental PPP1R2 message. Black boxes refer Alu repeats that are primate-specific. Number above the boxes indicates the location where the repeat interrupted the sequence. Grey box delimited with a black line in rhesus monkey PPP1R2P5 refer to a parental PPP1R2 insertion. Number on the top indicates where the insertion took place in the pseudogene, while numbers at the bottom show which region of the parental PPP1R2 was inserted. In orangutan an unknown sequence according to the current genome assembly was inserted in PPP1R10-like and is shown with a number on the bottom referring to the location. Gibbon PPP1R2P10 sequence was retrieved in a portion of the chromosome 5 not properly localized in the reference genomic sequence and so, even if the flanking genes were present in the same chromosome, the local could not be verified. The distances in dashed lines of the duplicated forms in human and orangutan are also indicated. RUNX1: Runt-related transcription factor 1; SETD4: SET domain containing 4; PCDH9/20: protocadherin 9/20; ST6GAL2: ST6 beta-galactosamide alpha-2,6-sialyltransferase 2; SLC5A7: solute carrier family 5 (choline transporter), member 7; JHDM1D: histone demethylase 1 homolog D; SLC37A3: solute carrier family 37 (glycerol-3-phosphate transporter), member 3.