Figure 2From: Endosymbiosis in trypanosomatids: the genomic cooperation between bacterium and host in the synthesis of essential amino acids is heavily influenced by multiple horizontal gene transfersCysteine and methionine synthesis and interconversion pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: L-serine; II: O-acetyl-serine; III: cysteine; IV: cystathionine; V: homocysteine; VI: methionine; VII: S-adenosyl-methionine; VIII: S-adenosyl-homocysteine; IX: succinyl-homoserine; X: homoserine; XI: aspartate 4-semialdehyde. Enzymes – 2.3.1.30: serine O-acetyltransferase; 2.5.1.47: cysteine synthase; 4.4.1.1: cystathionine gamma-lyase; 4.4.1.8: cystathionine beta-lyase; 2.1.1.x: 2.1.1.10, homocysteine S-methyltransferase, 2.1.1.13, 5-methyltetrahydrofolate–homocysteine methyltransferase, 2.1.1.14, 5-methyltetrahydropteroyltriglutamate–homocysteine methyltransferase; 2.5.1.6: S-adenosyl-methionine synthetase; 2.1.1.37: DNA (cytosine-5-)-methyltransferase; 3.3.1.1: adenosylhomocysteinase; 4.2.1.22: cystathionine beta-synthase; 2.5.1.48: cystathionine gamma-synthase; 2.3.1.46: homoserine O-succinyltransferase; 1.1.1.3: homoserine dehydrogenase. Abbreviations as for Figure 1.Back to article page