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Table 1 Comparison of main and accessory olfactory system components in rodent, frog, zebrafish and lamprey *note – teleost fish do not have a recognized vomeronasal organ nor an accessory olfactory bulb

From: The sea lamprey has a primordial accessory olfactory system

  MOE MOE/AOE AOE
  Rodent Frog Lamprey Zebrafish Rodent Frog Lamprey
Peripheral Cell Type Pseudostratified Ciliated Columnar [29] Ciliated [30, 31] Pseudostratified Ciliated Columnar [32, 33] Pseudostratified Ciliated Columnar and Microvillous [34] Pseudostratified Ciliated Columnar [35] Microvillous [31] Simple Ciliated Cuboidal [23, 24, 36]
Peripheral Genes OR, TAAR [10] OR [37], V1R [9] OR, TAAR, V1R [22] OR [38], TAAR [39], V1R, V2R [17] OR, V1R, V2R [10] V2R [40] OR, TAAR, V1R [15, 22]
Peripheral Projections To MOB [41] To MOB and AOB [31, 42] To MOB and DTN To MOB [34] To AOB [43] To MOB and AOB [31, 44] To MOB and DTN
Central Cell Type Mitral cells [45] Mitral cells [42, 46] Mitral cells [24, 33] Mitral cells [47, 48] Mitral cells [49] Mitral cells [44, 50] Mitral cells
Central Glomeruli Yes [51] Yes, [42, 50] Yes, loosely defined [52] Yes [34, 47, 53, 54] Yes [43] Yes [44] Yes, loosely defined [52]
Central Secondary Projections To olfactory cortex [55] To olfactory amygdala [56] To pallial areas and hypothalamus [26, 27] To habenula/limbic system output pathway [54] To amygdala (limbic area) and hypothalamus [57] To piriform cortex [58] To pallial areas and hypothalamus