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Table 2 Summary of relevant results: Genes putatively affected by positive selection. Loci showing gene-level iHS extreme empirical p-value after Bonferroni multiple comparison correction is considered taking into account the number of continental groups and the two methods applied

From: Distribution of events of positive selection and population differentiation in a metabolic pathway: the case of asparagine N-glycosylation

Sub-pathway Gene Continental Group p-value Corrected p-values
Precursor Biosynthesis ALG12 MENA 3 × 10-10 4.2 × 10-9
   EUR 1 × 10-10 1.4 × 10-9
   EASIA 5 × 10-11 7.0 × 10-10
  GANAB SSAFR 4 × 10-7 5.6 × 10-6
CNX_CRT EDEM3 OCE 1 × 10-10 1.4 × 10-9
  GCS1 MENA 2 × 10-14 2.8 × 10-13
   EUR 2 × 10-16 2.8 × 10-15
   CSASIA 2 × 10-6 2.8 × 10-5
  UGCGL2 SSAFR 4 × 10-5 5.6 × 10-4
Branching 1 FUT8 SSAFR 1 × 10-4 1.4 × 10-3
  MAN1A1 AME 5 × 10-13 7.0 × 10-12
  MAN1A2 SSAFR 8 × 10-4 1.12 × 10-2
  MAN2A1 SSAFR 4 × 10-23 5.6 × 10-22
   EASIA 3 × 10-10 4.2 × 10-9
  MGAT2 EASIA 4 × 10-7 5.6 × 10-6
  MGAT3 EASIA 1 × 10-14 1.4 × 10-13
Branching 2 MGAT5B MENA 1 × 10-7 1.4 × 10-6
   EUR 7 × 10-8 9.8 × 10-7
  ST8SIA3 MENA 5 × 10-10 7.0 × 10-9
   EUR 2 × 10-8 2.8 × 10-7
Substrates DPM1 MENA 5 × 10-12 7.0 × 10-11
   EUR 1 × 10-8 1.4 × 10-7
   CSASIA 2 × 10-16 2.8 × 10-15
  DOLPP1 CSASIA 2 × 10-5 2.8 × 10-4
  DPM2 EUR 5 × 10-7 7.0 × 10-6
  DPM3 EASIA 6 × 10-30 8.4 × 10-29
  1. Populations were grouped as following: SSAFR, MENA, EUR, CSASIA, EASIA, OCE and AME standing respectively for Sub-Saharan Africa, Middle East-North Africa, Europe, Central South Asia, East Asia, Oceania and America.
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BMC Ecology and Evolution

ISSN: 2730-7182

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