Genome coverage by 454 sequencing and comparative genome hybridization data for UGA10 and IC11. The x-axis represents the position on the reference Houston-1 genome. In the coverage plots ( A, C), the 100-nt average coverage of the reference genome (Houston-1) by reads from strains UGA10 ( A) and IC11 ( C) is shown with grey crosses. In comparative genome hybridization plots ( B, D), the log2-transformed ratio of the hybridization signal in UGA10 ( B) and IC11 ( D) relative to the reference Houston-1 genome is shown with grey crosses. In both analyses, the curve is smoothed using a Savitzky-Golay filter (shades of blue). The different tones correspond to different parameters of the filter: the darker the tone, the larger the window used for the calculation. Genomic regions (dashed boxes) are indicated with the following abbreviations: BAP = Bartonella prophage; HGIa, HGIb, HGIc = genomic islands; ROR, run-off replication.