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Figure 1 | BMC Evolutionary Biology

Figure 1

From: Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

Figure 1

Human perforin protein domains, transcript structure and genetic locus. The protein domains are shown along with the amino acids numbers they encompass as inferred from the mouse perforin structure [PBD:3NSJ]. Signal, secretion signal peptide; MACPF, membrane attack complex/perforin domain; EGF, epidermal growth factor-like domain; C2, C2 domain; CTE, c-terminal extension. The transcript [Refseq:NM_005041.4] is represented as a line where 1 cm = 500 bp, the black region represents the coding sequence (CDS), the yellow region represents the untranslated regions and the red ‘V’ shapes indicated positions where introns have been spliced out. The phasing of the CDS intron is indicated to left of the marker. The genes on Homo sapiens chromosome (Chr) 10 q22.1 (drawn as a black line, not to scale) are shown as arrowheads, with their gene symbols above. The direction of the arrowhead indicates the relative transcriptional orientation.

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