AA Positions^{a} | PAML Site Model (M8) p> 0.9 | PAML Branch-Site Model^{c} | FEL^{d} p< 0.2 | REL^{d} BF > 50 | AA Changes | Parallel Changes | Property Changes^{e} | Protein Domain | Functional Information^{f} | Clade^{g} |
---|---|---|---|---|---|---|---|---|---|---|
25 | Ser-Arg | Yes | SM, P, NEU-P.POS | LRR3 | B, C | |||||
28 | 0.07 | Leu-Trp | NP, NEU-P, NEU | LRR3 | A, D | |||||
Leu-Pro | NP, NEU-SM, NP, NEU | |||||||||
45 | 0.16 | Thr-Ile | Yes | SM, P, NEU-NP, NEU | LRR4 | A, F | ||||
104 | 0.17 | Leu-Val | NP, NEU-NP, NEU | LRR6 | ||||||
Leu-Ser | NP, NEU-SM, P, NEU | |||||||||
128 | 0.875 | Glu-Pro | P, NEG-SM, NP, NEU | LRR7 | D | |||||
133 | 0.723 | Asn-Lys | SM, P, NEU-P, POS | LRR7 | G | |||||
139 | 0.708 | Gly-Glu | SM, NP, NEU-P, NEG | LRR8 | Adjacent to site involved in interaction with MD2 | G | ||||
149 | 0.565 | Ser/Leu -Thr | SM, P, NEU/NP, NEU -SM, P, NEU | LRR8 | G | |||||
150 | 0.995 | 228.23 | His-Arg | Yes | P, POS-P, POS | LRR8 | A, B, C | |||
His-Asp | P, POS-SM, P, NEG | |||||||||
177 | 61.94 |
Asn-Thr Asn/Thr -Ile Asn-Lys Ile-Asn |
SM, P, NEU-SM, P, NEU SM, P, NEU/SM, P, NEU -NP, NEU SM, P, NEU-P, POS NP, NEU-SM, P, NEU | LRR9 | Adjacent to site involved in ligand binding and interaction with MD2 | A, C, G | ||||
179 | 0.992 | 0.07 | 647.96 |
Lys-Glu Glu-Gln Glu/Lys- Gln | Yes |
P, POS-P, NEG P, NEG-P, NEU P, NEG/P, POS-P, NEU | LRR9 | A, C, F | ||
183 | 0.12 | 51.06 |
Arg-Ser Arg-Thr |
P, POS-SM, P, NEU P, POS-SM, P, NEU | LRR9 | C, D | ||||
204 | Glu-His | Yes | P, NEG-P, POS | LRR10 | A, D | |||||
207 | 1.000 | 0.08 | 1563.58 |
Gly/Lys -Arg Arg-Lys Arg-Thr Lys-Arg |
SM, NP, NEU/P, POS -P, POS P, POS-P, POSP, POS-SM, P, NEU P, POS-P, POS | LRR10 | A, G, C, E | |||
212 | Leu-Val | Yes | P, POS-NP, NEU | LRR10 | A, B | |||||
221 | 0.1 | Val-Met | Yes | NP, NEU-NP, NEU | LRR11 | C, D, F | ||||
228 | 0.994 | 0.15 | 544.88 |
Asp/Ser/Cys -Asn Asp-Asn |
SM, P, NEG/SM, P, NEU/SM, NP, NEU -SM, P, NEU SM, P, NEG-SM, P, NEU | LRR11 | A, G | |||
230 | 0.978 |
Gly/Glu/Asp -Arg Asp-His |
SM, NP, NEU/P, NEG/SM, P, NEG -P.POS SM, P, NEG-P, POS | LRR11 | A, E | |||||
239 | 50.32 | Cys-Tyr | Yes | SM, NP, NEU-P, NEU | LRR12 | B, D, G | ||||
247 | 0.14 | 86.14 |
Ile-Thr Thr-Ile |
NP, NEU-SM, P, NEU SM, P, NEU-NP, NEU | LRR12 | Adjacent to site involved in interaction with ligand binding | C, G | |||
250 ^{b} | 0.936 |
Asp/Ala -Lys Asp/Lys/Ala -Asn Asn-Lys |
SM, P, NEG/SM, NP, NEU -P, POS SM, P, NEG/P, POS/SM, NP, NEU -SM, P, NEU SM, P, NEU-P, POS | LRR12 | Ligand binding | A, E, G | ||||
265 | Phe-Leu | Yes | NP, NEU-NP, NEU | LRR13 | B, E | |||||
272 | 0.997 | 0.13 | 188.28 |
Gly/Asp- His Gly-His His-Gly |
SM, NP, NEU/SM, P, NEG-P, POS SM, NP, NEU-P, POS P, POS-SM, NP, NEU | LRR13 | Adjacent to site involved in interaction with ligand binding | A, C | ||
280 | 0.952 | 0.18 | 191.07 |
Glu-Ala Gln/Glu- Ala | Yes |
P, NEG-SM, NP, NEU P, NEU/P, NEG-SM, NP, NEU | LRR13 | A, B, E | ||
302 | 0.624 | His-Arg | P, POS-P.POS | LRR14 | D | |||||
304 | 55.05 |
Asp-Asn Asn-Pro |
SM, P, NEG-SM, P, NEU SM, P, NEU-SM, NP, NEU | LRR14 | G | |||||
324 | 0.996 | 301.87 |
Asn-Ser Asn-Lys Gly-Asn |
SM, P, NEU-SM, P, NEU SM, P, NEU-P, POS SM, NP, NEU-SM, P, NEU | LRR15 | Adjacent to site involved in interaction with ligand binding (hydrogen bond) | C, E, G | |||
342 | 53.56 |
Asn-Ser Asn/Ser- Thr |
SM, P, NEU-SM, P, NEU SM, P, NEU/SM, P, NEU-SM, P, NEU | LRR16 | Adjacent to site involved in interaction with ligand binding (hydrogen bond) | A | ||||
351 | 0.17 | Ile/Ala-Val | NP, NEU/SM, NP, NEU-NP, NEU | LRR16 | Adjacent to site involved in interaction with ligand binding (hydrophobic interaction) | G | ||||
368 | 0.576 | Ile-Thr | NP, NEU-SM, P, NEU | LRR17 | Adjacent to site involved in interaction with ligand binding (hydrophobic interaction) | G | ||||
404 | 0.08 | Leu-Met | NP, NEU-NP, NEU | LRR18 | C | |||||
408 | Ile-Thr | Yes | NP, NEU-SM, P, NEU | LRR19 | A, G | |||||
409 | 0.19 |
Leu/Ile/Phe -Val |
NP, NEU/NP, NEU/NP, NEU -NP, NEU | LRR19 | A | |||||
482 | 0.16 |
Ser/Trp- Phe Phe/Ser/Trp -Leu |
SM, P, NEU/P, NEU-NP, NEU NP, NEU/SM, P, NEU/P, NEU -NP, NEU | LRR22 | A | |||||
542 | 0.903 | Met-Thr | Yes | NP, NEU-SM, P, NEU | LRRCT | A, D | ||||
551 | 0.938 |
Ile-Val Val-Ile | Yes |
NP, NEU-NP, NEU NP, NEU-NP, NEU | Transmembrane | B, F | ||||
559 | 0.16 | Val-Ala | NP, NEU-SM, NP, NEU | Transmembrane | G | |||||
690 | 0.564 | Arg-Gln | P, POS-P, NEU | TIR | D | |||||
740 | 0.790 | Glu-Asp | P, NEG-SM, P, NEG | TIR | G | |||||
742 | 0.697 | Asn-Arg | SM, P, NEU-P, POS | TIR | G | |||||
743 | 0.18 | Gln-Glu | P, NEU-P, NEG | TIR | A, F |