Correlation of genetic distance matrices. This figure shows the box-plot distribution of Pearson’s correlation coefficient for the genetic distance matrices of a pair of proteins for the different datasets. Heavy bars represent mean values, boxes indicate 25 and 75 percentiles and bars indicate 5 and 95 percentiles. POS indicates interacting proteins, and NEG indicates non-interacting proteins. P-values of the Mann–Whitney tests comparing the distributions of interacting and non-interacting protein datasets are indicated for each pair.