Figure 2

Signature plots for two host genes associated with HIV-1, under potential recent selection in the Biaka when compared to the Mbuti. The x-axes show chromosomal positions for CUL5 (panel A) and TRIM5 (panel B). The y-axes map λ scores across moving windows of SNPs, used to examine the genome for signatures of selection [19]. Note that the x- and y-axes for the two genes use different scales. The lines represent values calculated for heterozygosity in Biaka (blue) and Mbuti (red) within populations (low heterozygosity when lines are at high values), and for the variance of F _ST between populations (green; high variance of F _ST when lines are at high values). Signatures of “new” or recent selection for CUL5 and TRIM5 in the Biaka are indicated by the overlapping peaks for Biaka heterozygosity and for variance of F _ST [19]. The positions of the genes are indicated in the plots.