MHC class II DQB diversity in the Japanese black bear, Ursus thibetanus japonicus

Table 2 Comparison of non-synonymous ( d _N ) and synonymous ( d _S ) substitution rates at the DQB exon 2 region

Species	Gene	No. of sample	No. of variant	Length	PBRs				Non-PBRs				Entire exon 2 region
Species	Gene	No. of sample	No. of variant	Length	d_N/dx_S	d _N			d_N/d_S	d _N			d_N/d_S	d _N			d _S
*Ursidae*
Japanese black bear^a	DQB	184^k	43^k	267 bp	3.83	0.11	±	0.04	0.63	0.02	±	0.01	1.48	0.04	±	0.01	0.03	±	0.01
Giant panda^b	DQB1	121	6	267 bp	1.33	0.02	±	0.06	0.47	0.01	±	0.02	0.71	0.02	±	0.05	0.01	±	0.03
Brown bear^*c	DRB	38	19	267 bp	4.09	0.06	±	0.29	0.72	0.02	±	0.05	1.53	0.02	±	0.07	0.02	±	0.11
*Other carnivores*
African wild dog^d	DRB	320	19	267 bp	5.28	0.06	±	0.21	0.56	0.01	±	0.02	1.72	0.02	±	0.04	0.02	±	0.07
Namibian cheetah^*e	DRB	139	4	237 bp	2.01	0.06	±	0.25	0.37	0.01	±	0.05	0.76	0.04	±	0.13	0.02	±	0.10
European mink^f	DRB	20	9	228 bp	1.78	0.06	±	0.16	0.26	0.01	±	0.02	0.65	0.03	±	0.09	0.02	±	0.06
*Non-carnivores*
Water buffalo^{*g, h}	DQB	210	22	243 bp	2.65	0.07	±	0.37	0.92	0.03	±	0.13	1.34	0.03	±	0.14	0.03	±	0.19
Ma's night monkeyⁱ	DQB1	19	14	246 bp	2.71	0.05	±	0.19	0.95	0.02	±	0.07	1.39	0.02	±	0.07	0.02	±	0.10
Yellow necked mouse^j	DRB	146	27	216 bp	7.75	0.09	±	0.38	1.13	0.02	±	0.06	2.46	0.02	±	0.05	0.02	±	0.12

The d_N and d_S are estimated by the modified Nei-Gojobori method.
^a: present study; ^b: Chen et al. [34]; ^c: Goda et al. [36]; ^d: Marsden et al. [91];
^e: Castro-Prieto et al. [92]; ^f: Becker et al. [93]; ^g: Niranjan et al. [94]; ^h: Sena et al. [95];
ⁱ: Diaz et al. [96]; ^j: Meyer-Lucht and Sommer [97]; ^k: An individual that has the putative pseudogene, Urth-DQB*3201, is excluded.
^*: The number of MHC variants may be derived from multiple loci.

ISSN: 2730-7182