Figure 1
From: Evolution of major histocompatibility complex class I and class II genes in the brown bear
Amino acid sequences of MHC alleles in the Scandinavian brown bear. Positions in the alignment correspond to Human Leukocyte Antigen (HLA, after Reche & Reinherz, 2003). Dots mark identity to the reference sequence. The putative Antigen Binding Sites consensus positions (HLA-A, HLA-B and HLA-C for MHC class I 2nd exon alleles, HLA-DRβ for MHC class II DRB 2nd exon, HLA-DQα for MHC class II DQA 2nd exon and HLA-DQβ for MHC class II DQB 2nd exon; after Reche & Reinherz, 2003) are marked with ‘+’. Positively selected amino acid sites identified by the Bayes empirical Bayes procedure are shaded (** - posterior probability > 99%, * - posterior probability >95%).