Table 1 The distribution of domains identified in calpain genes in the three domains of life

ADK

Adenylate kinase

*

*

*

Cellular energy homeostasis

Berry MB et al., 1998

C2

Protein kinase C conserved region 2 (CalB)

*

*

*

Signal transduction or membrane trafficking

Ponting CP et al., 1996

C2L

Calpain domain III

*

Regulation of calpain activity

Sorimachi H et al., 2011

CysPc

Calpain-like protease catalytic domain

*

*

Apoptosis, membrane fusion, cell motility, and signal transduction

Sorimachi H et al., 2011

DUF1935

Domain of unknown function 1935

*

Unknown

Bateman A et al., 2010

EF

EF hands

*

*

Ca²⁺-binding

Nakayama S et al., 1992

GuKc

Guanylate kinase homologs

*

*

*

Active Guanylate kinase catalyze ATP-dependent phosphorylation of GMP to GDP

Kuhlendahl S et al., 1998

hATC

hAT family dimerization domain

*

*

Proposed to participate in regulation of transcription

Rubin et al., 2001

LIM

Zinc-binding domain present in Lin-11, Isl-1, Mec-3

*

*

*

Zn²⁺-binding, mediate protein-protein interactions

Perez-Alvarado GC et al., 1992

Nter

N-terminal anchor helix

*

Participate in classical calpain conformation change

Sorimachi H et al., 2011

MORN

Membrane Occupation and Recognition Nexus

*

*

Unknown

Takeshima et al., 2000

PEF

Calpain domain IV

*

Ca²⁺-binding

Sorimachi H et al., 2011

PUB

PUB domain

*

*

AAA ATPase binding domain

Allen MD et al., 2006

SOL

Small optic lobes

*

Unknown

Kamei M et al., 1998

TM(L/S)

(Long or Short) Transmembrane motifs

*

*

Unknown

Corall and Ersfeld K 2007

TPR

Tetratricopeptide repeats

*

*

*

Mediate protein-protein interactions

Palmer CP et al., 2004

UBA

UBA/TS-N domain

*

*

*

Ubiquitin binding

Dieckmann T et al., 1998

UEV

UEV domain

*

Functions in both HIV-1 budding and the vacuolar protein sorting (VPS) pathway in human

Wagner KU et al., 2003

Vps23

Vps23 core domain

*

Stable ESCRT-I complex

Teo H et al., 2006

WW

Domain with two highly conserved tryptophans

*

Binds proline-rich polypeptides

Bork et al., 1994

Zf_GRF

GRF zinc finger

*

*

Proposed in nucleic acid binding

Krishna SS et al., 2001

Zf_CCHH

Zinc-finger (CX5CX6HX5H) motif

*

DNA strand break repair, DNA metabolism

Iles N et al., 2007

Zn

Zinc finger domain in Ran-binding proteins

*

*

*

RanGDP binding

Krishna SS et al., 2001

AAA

AAA ATPase domain

*

*

ATPases associated with diverse cellular activities

Hanson PI et al. 2005

MIT

Microtubule interacting domain

*

*

Intracellular trafficking

Phillips SA et al., 2001