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Table 1 Newly defined subfamilies within glycoside hydrolase family GH5

From: Evolution, substrate specificity and subfamily classification of glycoside hydrolase family 5 (GH5)

New GH5 subfamily

Historical subfamily

Number of sequences

Present taxonomical distribution

EC number

Representative PDB structure

GH5_1

A1b

133

Archaea Bacteria Eukaryota

3.2.1.4

2ZUN

3.2.1.73

3.2.1.91

GH5_2

A2b

245

Bacteria Eukaryota

3.2.1.4

2A3H

3.2.1.132

GH5_4

A3 + A4b

160

Bacteria Eukaryota

3.2.1.4

2JEQ

3.2.1.151

3.2.1.73

3.2.1.8

GH5_5

A5 + A6b,c,e

123

Bacteria Eukaryota

3.2.1.4

IGZJ

GH5_7

A7d

133

Archaea Bacteria Eukaryota

3.2.1.25

IRH9

3.2.1. 78

2.4.1.-

GH5_8

A8d

71

Bacteria Eukaryota

3.2.1.78

2WHL

GH5_9

A9e

107

Eukaryota

3.2.1.58

3N9K

3.2.1.75

3.2.1.21

GH5_10

A10e,f

19

Bacteria Eukaryota (Metazoa)

3.2.1.78

2C0H

GH5_11

 

19

Eukaryota (Plants;Fungi)

ND

 

GH5_12

 

42

Bacteria Eukaryota

3.2.1.21

 

3.2.1.45

GH5_13

 

59

Bacteria

ND

 

GH5_14

 

15

Eukaryota (Plants)

3.2.1.58

 

GH5_15

 

10

Eukaryota (Fungi)

3.2.1.75

 

GH5_16

 

10

Eukaryota (Fungi)

3.2.1.164

 

GH5_17

 

5

Bacteria

3.2.1.78

 

GH5_18

 

24

Bacteria

ND

 

GH5_19

 

23

Archaea

ND

 

GH5_20

 

17

Eukaryota (Stramenopiles)

ND

 

GH5_21

 

10

Bacteria

3.2.1.8

 

GH5_22

 

12

Bacteria Eukaryota

3.2.1.4

 

GH5_23

 

5

Eukaryota (Fungi)

3.2.1.149

 

3.2.1.168

GH5_24

 

5

Eukaryota (Fungi)

ND

 

GH5_25

 

16

Bacteria

3.2.1.4

3MMW

3.2.1.78

GH5_26

 

17

Bacteria

3.2.1.4

 

3.2.1.73

GH5_27

 

5

Eukaryota (Metazoa;Fungi)

3.2.1.123

 

GH5_28

 

8

Bacteria

3.2.1.123

2OSX

GH5_29

 

5

Bacteria

3.2.1.123

 

GH5_30

 

5

Eukaryota (Fungi)

ND

 

GH5_31

 

5

Eukaryota (Fungi)

3.2.1.-g

 

GH5_32

 

5

Eukaryota (Plants; Stramenopiles)

ND

 

GH5_33

 

9

Eukaryota (Stramenopiles)

ND

 

GH5_34

 

5

Bacteria

3.2.1.-g

2Y8K

GH5_35

 

5

Bacteria

ND

 

GH5_36

 

23

Bacteria

3.2.1.73

IVJZ

3.2.1.78

GH5_37

 

19

Bacteria

3.2.1.4

ICEN

3.2.1.73

3.2.1.74

GH5_38

 

10

Bacteria

3.2.1.-h

 

GH5_39

 

7

Bacteria

3.2.1.4

 

GH5_40

 

8

Bacteria

ND

 

GH5_41

 

14

Bacteria

ND

 

GH5_42

 

9

Bacteria

ND

 

GH5_43

 

11

Bacteria

ND

 

GH5_44

 

24

Bacteria

ND

 

GH5_45

 

5

Bacteria

ND

 

GH5_46

 

15

Bacteria

3.2.1.-h

 

GH5_47

 

6

Bacteria

ND

 

GH5_48

 

18

Bacteria

3.2.1.-h

 

GH5_49

 

20

Eukaryota (Fungi)

ND

 

GH5_50

 

7

Eukaryota (Fungi)

ND

 

GH5_51

 

5

Bacteria Eukaryota (Fungi)

ND

 

GH5_52

 

6

Bacteria

3.2.1.74

 

GH5_53

 

6

Bacteria

3.2.1.74

 
  1. ND Activity not determined yet.
  2. aExperimentally determined.
  3. bsee [16].
  4. csee [17].
  5. dsee [18].
  6. esee [19].
  7. fsee [20].
  8. gEC numbers not yet defined.
  9. hActive enzyme(s) present but with unclear EC number(s).
  10. * See http://www.cazy.org for most recent information.
  11. Historical names for some subfamilies are provided, along with the taxonomical range, the characterization level and structural information from representative structures. Known enzyme activities in family GH5 are provided using the following Enzyme Classification (EC) numbers and corresponding activities: 3.2.1.4 – endo-β-1,4-glucanase or cellulase; 3.2.1.8 – endo-β-1,4-xylanase; 3.2.1.21 – β-glucosidase; 3.2.1.25 – β-mannosidase; 3.2.1.45 – β-glucocerebrosidase; 3.2.1.58 – glucan β-1,3-glucosidase; 3.2.1.73 – licheninase; 3.2.1.74 – cellodextrinase; 3.2.1.75 – glucan endo-β-1,6-glucosidase; 3.2.1.78 – mannan endo-β-1,4-mannosidase or endo-β-1,4-mannanase; 3.2.1.91 – cellulose β-1,4-cellobiosidase or cellobiohydrolase; 3.2.1.123 – endoglycoceramidase; 3.2.1.132 – chitosanase; 3.2.1.149 – β-primeverosidase; 3.2.1.151 – xyloglucan-specific endo-β-1,4-glucanase; 3.2.1.164 – endo-β-1,6-galactanase; 3.2.1.168 – hesperidin 6-O-α-L-rhamnosyl-β-glucosidase; 3.2.1.- – undefined EC numbers for β-1,3-mannanase/β-1,3-glucomannanase or for arabinoxylan-specific β-xylanase or still unclear EC numbers depending on the subfamily (see notes and text); 2.4.1.- – β-mannan transglycosidase.