Genome-wide DNA methylation analyses in the brain reveal four differentially methylated regions between humans and non-human primates

Table 2 The four DMRs (differentially methylated regions) validated by the MassARRAY analysis

DMR ID^a	Gene	Human PCR region^b	Rhesus PCR region	H1	H2	H3	M1	M2	M3	Differences	P value^c
143	RNF32	chr7:156125452-156125599	chr3:193770671-193770806	0.287	0.260	0.310	0.953	0.903	0.905	−0.647	8.2E-06
103	K6IRS2	chr12:51281338-51281660	chr11:49678948-49679270	0.225	0.235	0.242	0.951	0.801	0.738	−0.596	7.2E-04
8	ICAM1	chr19:10242793-10243123	chr19:10081432-10081787	0.148	0.145	0.160	0.540	0.540	0.530	−0.383	2.8E-07
13	ProSAPiP1	chr20:3096748-3097085	chr10:36475835-36476155	0.400	0.355	0.446	0.183	0.170	0.130	0.239	1.5E-03

^athe ID number of the 150 candidate DMRs identified by MeDIP-Chip.
^bthe coordinates are based on hg18 build.
^cthe P values obtained by two-sided t-test, and all P values are smaller than 0.05 after Benjamini FDR adjustments.

ISSN: 2730-7182