Figure 4

Bayesian phylogenetic tree of PYHIN pyrin domains across placental and marsupial mammals, rooted with marsupial sequences. Where a pyrin domain is clearly from the same gene as a HIN domain, labels are the same as Figure 3 (e.g. Cow 1). Some pyrin domains from low coverage genomes cannot definitively be linked to particular HIN domains, and are indicated with letters (e.g. Hyrax a). Posterior probabilities >0.7 are shown above nodes. Clades which were supported by PhyML analysis with likelihood-ratio test values >0.74 are shown by dots on the nodes. For a limited number of important nodes the PhyML likelihood-ratio test values are shown as a number below the node. Dotted lines indicate the three distinct clades: marsupial pyrin, pyrin domains from placental AIM2 sequences, and pyrin domains from placental non-AIM2 (IFI) sequences. Sequences used are defined in Table 1 and Additional File 2: Table S1, and alignment in Additional File 4: Figure S4.