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Table 4 Enriched biological process GO a terms in protein families born at the LCA b of the three major metazoan groups and the LCA of metazoans

From: Exploring metazoan evolution through dynamic and holistic changes in protein families and domains

Groups

GO terms

Description

P-value

Families born at the LCA of metazoans

 
 

GO:0006355

regulation of transcription, DNA-dependent

1.29E-106

 

GO:0006836

neurotransmitter transport

7.59E-11

 

GO:0007275

multicellular organismal development

1.25E-09

 

GO:0006637

acyl-CoA metabolic process

4.33E-08

 

GO:0007186

G-protein coupled receptor protein signaling pathway

1.35E-07

 

GO:0007040

lysosome organization and biogenesis

4.78E-06

 

GO:0007223

Wnt receptor signaling pathway, calcium modulating pathway

4.78E-06

 

GO:0030704

vitelline membrane formation

6.47E-06

 

GO:0006508

proteolysis

1.48E-05

 

GO:0006094

gluconeogenesis

1.90E-05

 

GO:0006665

sphingolipid metabolic process

3.24E-05

 

GO:0007179

transforming growth factor beta receptor signaling pathway

3.24E-05

 

GO:0006869

lipid transport

5.22E-05

 

GO:0045449

regulation of transcription

9.33E-05

 

GO:0006835

dicarboxylic acid transport

3.50E-04

 

GO:0007600

sensory perception

3.50E-04

 

GO:0045087

innate immune response

8.15E-04

 

GO:0007026

negative regulation of microtubule depolymerization

9.14E-04

Families born at the LCA of nematodes

 
 

GO:0051085

chaperone cofactor-dependent protein folding

9.14E-04

 

GO:0007186

G-protein coupled receptor protein signaling pathway

3.54E-116

 

GO:0016998

cell wall catabolic process

7.49E-06

 

GO:0005992

trehalose biosynthetic process

2.37E-05

 

GO:0006812

cation transport

2.98E-04

Families born at the LCA of arthropods

 
 

GO:0006030

chitin metabolic process

1.08E-22

 

GO:0006814

sodium ion transport

2.32E-18

 

GO:0006950

response to stress

2.02E-11

 

GO:0007608

sensory perception of smell

4.74E-11

Families born at the LCA of vertebrates

 
 

GO:0007186

G-protein coupled receptor protein signaling pathway

7.41E-155

 

GO:0006955

immune response

1.29E-39

 

GO:0001558

regulation of cell growth

2.57E-10

 

GO:0007154

cell communication

4.19E-10

 

GO:0050909

sensory perception of taste

4.88E-10

 

GO:0045087

innate immune response

1.04E-09

 

GO:0015671

oxygen transport

7.68E-09

 

GO:0048468

cell development

1.03E-08

 

GO:0006691

leukotriene metabolic process

7.08E-08

 

GO:0042981

regulation of apoptosis

1.99E-07

 

GO:0019882

antigen processing and presentation

3.04E-07

 

GO:0009395

phospholipid catabolic process

3.60E-06

 

GO:0006915

apoptosis

5.43E-06

 

GO:0016049

cell growth

2.51E-05

 

GO:0006486

protein amino acid glycosylation

3.09E-05

 

GO:0006952

defense response

5.80E-05

 

GO:0006071

glycerol metabolic process

8.96E-05

 

GO:0009607

response to biotic stimulus

2.40E-04

 

GO:0030178

negative regulation of Wnt receptor signaling pathway

2.54E-04

 

GO:0043065

positive regulation of apoptosis

2.54E-04

  1. a GO, Gene Onthology; b LCA, Last Common Ancestor.