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Table 1 Median effective concentrations (EC50) of glucocorticoid-dependent stimulation of in vitro transactivation activity by Acipenser ruthenus (Ar) and Pantodon buchholzi (Pb) GR

From: Evidence for a divergence in function between two glucocorticoid receptors from a basal teleost

 

11- deoxycortisol

Corticosterone

Cortisol

PbGR1

7.1 ± 2.2

#

10.4 ± 1.4

PbGR2b

0.2 ± 0.02

36 ± 2.6

2.7 ± 0.6

ArGR

11.5 ± 4.7

#

21.6 ± 3.1

  1. Values represent n = 3, EC50 nM ± Standard error.
  2. # = Unable to calculate EC50, because activity did not reach a plateau at 10-6 M hormone concentration.