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Figure 8 | BMC Evolutionary Biology

Figure 8

From: Molecular evolution of a-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization

Figure 8

Open Reading Frame Analysis of Human AKAP7δ insertion-deletion variants. Human AKAP7δ splice variants were assessed for open reading frames using the NCBI ORF finder. (A-C) Coding and protein sequence for the AKAP7δ amino terminus is indicated by a dotted box, reading frame initiation is indicated by an arrow, and the AKAP7 NLS has a dotted underline. The AKAP7 RI/RII binding domain (if present) is identified in a solid box and termination codons are indicated by an (*). (A) The 5’ insertion identified in the majority of human tissues contains two termination codons and results in a reading frame shift yielding the AKAP7γ splice variant. (B) The 5’ insertion combined with deletion of exon-6 results in a truncated protein with the AKAP7γ amino terminus. (C) The 5’ insertion combined with the insertion of the AKAP7β exon yields a protein with the AKAP7γ amino terminus, the AKAP7 NLS, the protein region previously identified only in AKAP7β, and the AKAP7 RI/RII binding domain.

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