Figure 1From: Molecular evolution of a-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalizationCo-Evolution of PKA-R and AKAP7 RI/RII binding domains. A phylogenetic tree was constructed using PKA-R amino acid sequences. Bootstrap values are indicated next to each branch. PKA-R gene duplication events are indicated by *. PKA-R and AKAP7 protein families identified in species composing each clade are shown adjacent to the PKA-R phylogenetic tree. The PKA-R dimerization/docking (D/D) domain is identified in invertebrate and vertebrate species, while the AKAP7 RI/RII binding domain appears in vertebrate species following PKA-R gene duplication events. The PKA-RIIβ subunit in zebrafish lacks the AKAP7 RI/RII binding domain.Back to article page