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Table 2 Potency and efficacy of the chicken 1–34 N-terminal PTH peptides on PTH1R and PTH3R cAMP production

From: Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken

 

PTH1R

PTH3R

EC50 (nM)

95% Confidence Intervals (nM)

Emax (pmol/well)

EC50 (nM)

95% Confidence Intervals (nM)

Emax (pmol/well)

PTH

92.1

11.4 to 743.5

6.03 ± 0.78

22.1

7.1 to 68.4

144.7 ± 20.02

PTHrP

22.7

10.7 to 48.4

17.21 ± 1.84 *

2.5

1 to 6.1

119.9 ± 11.76

PTH-L

7.7

1.5 to 39.9

9.13 ± 1.44

306.9

27.7 to 3.4e+10

12.6 ± 2.13 *

  1. Peptides tested, cAMP production, 95% confidence intervals and maximal cAMP production Emax (mean ± SEM). Each result is an average of 3 experiments carried out in triplicate. * indicates statistical significance compared to other peptides (p < 0.05).