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Table 2 Potency and efficacy of the chicken 1–34 N-terminal PTH peptides on PTH1R and PTH3R cAMP production

From: Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken

  PTH1R PTH3R
EC50 (nM) 95% Confidence Intervals (nM) Emax (pmol/well) EC50 (nM) 95% Confidence Intervals (nM) Emax (pmol/well)
PTH 92.1 11.4 to 743.5 6.03 ± 0.78 22.1 7.1 to 68.4 144.7 ± 20.02
PTHrP 22.7 10.7 to 48.4 17.21 ± 1.84 * 2.5 1 to 6.1 119.9 ± 11.76
PTH-L 7.7 1.5 to 39.9 9.13 ± 1.44 306.9 27.7 to 3.4e+10 12.6 ± 2.13 *
  1. Peptides tested, cAMP production, 95% confidence intervals and maximal cAMP production Emax (mean ± SEM). Each result is an average of 3 experiments carried out in triplicate. * indicates statistical significance compared to other peptides (p < 0.05).