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Figure 1 | BMC Evolutionary Biology

Figure 1

From: Expression level, cellular compartment and metabolic network position all influence the average selective constraint on mammalian enzymes

Figure 1

The human metabolic network. A) The full reaction network used in this analysis. Colors correspond to the compartment in which each reaction occurs. The network was visualized with Gephi 0.7 [63] using the Force-Atlas layout algorithm. B) Schematic view of network construction. Reactions that share a metabolite are joined by edges. Each reaction in A may also be associated with one or more genes; it is these genes for which we calculate the selective constraint.

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BMC Ecology and Evolution

ISSN: 2730-7182

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