Figure 5

Predicted B-epitopes of the NA protein. (A) Comparison of pandemic human (red) vs. non-pandemic human (blue). (B) Comparison of pandemic human (red) vs. swine (black) predictions. The BepiPred score is represented as a function of the amino acid position along the protein. Scores above the 0.35 threshold (horizontal broken line) are considered significant (see Methods). Epitope differences between pandemic and non-pandemic NA proteins are highlighted for regions 37-43, 76-84, 261-264, 268-276, and 351-353 (dotted vertical lines). Asterisks (*) indicate the sites identified to be under positive selection during host-switch events. The chevron pattern locates loop 150.