Figure 5From: Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discoveryPhyletic distribution of phosphoinositide kinases. Shown is a summary of PIK orthologs and paralogs (relative to mammals) across major eukaryotic groups. Cladogram at the top represents relative evolutionary relationships among these groups according to the Tree of Life web project [46].Back to article page