Figure 4

Timetrees for all known primate and rodent malarial parasites. Time is shown in millions of years ago (Mya). Divergence times were estimated using two calibrations points: the host divergence Papio/Macaca (6-14.3 Mya) (Figure 4A) and then a second scenario that includes a minimum of 23.5 Mya for the divergence of the pathogens in Homo and Macaca (Figure 4B). The horizontal bars show the credibility intervals (CrIs); CrIs from MDT are shown in yellow, those from BEAST in blue and the overlap between the two is shown in green. Vertical lines allow comparing the two timetrees. Notice that the two methods lead to similar estimates under scenario 4B as evidenced by the overlap in their CrIs (green). Plasmodium sp. (A-E) are those found in lemurs.