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Table 3 Maximum field allele frequencies for non-synonymous mutations in PfSERCA (PFA0310c, PfATP6)

From: Protein-based signatures of functional evolution in Plasmodium falciparum

Mutation

Frequency (%)

Location

Reference

R37K

100

Venezuela

[54]

K67R

3

Ghana

[54]

K88E

1

Tanzania

[54]

I89T

38

Philippines

[54]

S176N

3

Malawi

[54]

V229I

< 1

Zanzibar

[55]

I230T

3

Iran

[54]

H243Y

5

Malawi

[54]

A338V

1

Tanzania

[54]

L402V

28

Brazil

[56]

D405N

1

Tanzania

[54]

E431K

58

Ethiopia

[57]

E432K

36

Cameroon

[58]

D436N

3

Tanzania

[54]

A438D

18

Vanuatu

[54]

N462D

10

Venezuela

[54]

N463S

3

Vietnam

[59]

464 del

2

Cambodia

[60]

N465S

16

Thailand

[1]

S466N

35

Peru

[61]

S529I

3

Tanzania

[54]

K561N

1

Niger

[62]

N569K

36

Zanzibar

[55]

G585D

< 1

Zanzibar

[55]

T602I

< 1

Zanzibar

[55]

L610I

1

Tanzania

[54]

K611N

< 1

Zanzibar

[55]

N612D

< 1

Zanzibar

[55]

A621D

< 1

Zanzibar

[55]

A623E

4

Ethiopia

[57]

A630S

58

Brazil

[56]

G632E

3

Malawi

[54]

T635K

16

Madagascar

[54]

E637G

< 1

Zanzibar

[55]

G639D

90

Venezuela

[54]

S641G

< 1

Zanzibar

[55]

E643Q

1

Zanzibar

[55]

N644I

1

Zanzibar

[55]

K649E

< 1

Zanzibar

[55]

L650W

2

Bangladesh

[54]

T657I

3

Malawi

[54]

N683K

9

Bangladesh

[54]

I723V

3

Tanzania

[54]

H747Y

11

Madagascar

[54]

S769N

4

Ethiopia

[57]

K771A

4

Angola

[63]

K776N

1

Angola

[63]

K783E

1

Tanzania

[54]

G805E

3

Malawi

[54]

R809G

< 1

Zanzibar

[55]

844 del

77

Peru

[61]

D845N

3

Tanzania

[54]

E847K

2

Thailand

[1]

T857S

1

Tanzania

[54]

A1115G

4

Papua New Guinea

[54]

V1169I

24

Brazil

[54]

S1187T

3

Ghana

[54]

D1228E

3

Ghana

[54]

  1. 3D7 sequence was used as reference. Only studies where alleles were determined for at least ten samples were included. Samples with mixed infections were included in each numerator.