Examples of conversion events in the human β-globin cluster. Blue underlays in the plots represent conversion regions. Black lines show sequence similarities between a human region and its human paralog, and brown lines between the human region and its ortholog in the outgroup species. In each plot, the y-axis corresponds to the percent identity of the two sequences (50%-100%). Note how the black paralogs lie above the brown orthologs in the converted region, but fall below them in the flanking regions. (A) depicts a conversion event in the first exon and intron of the human δ gene, copied from the human β gene (standard coordinates for this human chromosome have the genes of the β-globin cluster transcribed from right to left). This event was detected using the marmoset ortholog of human δ. (B) shows a converted region covering the human γ2 gene. Its paralog is γ1 in human, and the gibbon ortholog of human γ2 was used for this conversion observation.