Figure 4

Genomic neighborhood surrounding the lysozyme ( Lyz ) gene. The relative organization and orientation (with arrowheads indicating the direction of transcription) of genes near the Lyz genes in representative diverse vertebrate genomes. Species and chromosomes (or contigs or scaffolds) are from Ensembl [16], and are shown under each gene array. Gene sizes and distances between genes are not to scale. The distance between the human CFPS6 and YEATS4 genes is about 90 kb. Gene symbols are: CPM, Carboxypeptidase M; CPSF6, Cleavage and polyadenylation specificity factor subunit 6; YEATS4, YEATS domain-containing protein 4 (Synonym: Gas41, Glioma-amplified sequence 41); FRS2, Fibroblast growth factor receptor substrate 2 (FGFR substrate 2); C12orf71, Chromosome 12 open reading frame 71; V1r, a member of the family of vomeronasal receptor gene family; Nup107, nucleoprotein 107 kDa. By necessity, the cow Lyz genes are, shown on two lines, but are actually contiguous in the genome. The opossum Lyz genes are at two non-adjacent locations on chromosome 8.