Table 2 Positive selection in the TLR1 gene family in birds and mammals

Mammalian TLR1

12

M1A vs. M2A

15.87

3.58E-04

ω= 3.46 (p = 0.02)

286Q, 599S*

M7 vs. M8

26.84

1.49E-06

ω= 2.60 (p = 0.04)

174T, 238A, 286Q*, 599S**

M8A vs. M8

20.17

3.54E-06

ω= 2.84 (p = 0.02)

Mammalian TLR6

15

M1A vs. M2A

12.73

1.72E-03

ω = 2.84 (p = 0.02)

90L*, 296D

M7 vs. M8

20.66

3.26E-05

ω = 2.02 (p = 0.04)

90L

M8A vs. M8

17.79

1.24E-05

Mammalian TLR10

12

M1A vs. M2A

0

1.00

ns

M7 vs. M8

7.78

2.05E-02

ω = 2.47 (p = 0.02)

ns

M8A vs. M8

6.06

6.89E-03

Mammalian TLR2

27

M1A vs. M2A

0

1.00

ns

M7 vs. M8

14.65

6.58E-04

ω = 2.07 (p = 0.02)

453G, 766M

M8A vs. M8

8.21

2.09E-03

Avian TLR1A

4

M1A vs. M2A

3.44

0.18

ns

M7 vs. M8

3.63

0.16

ns

M8A vs. M8

3.39

3.28E-02

Avian TLR1B

4

M1A vs. M2A

0

1.00

ns

M7 vs. M8

0.21

0.90

ns

M8A vs. M8

0

0.48

Avian TLR2A

4

M1A vs. M2A

4.82

8.98E-02

ω = 2.85 (p = 0.04)

ns

M7 vs. M8

6.81

3.32E-02

ω = 2.19 (p = 0.09)

184T, 304N, 506S

M8A vs. M8

4.75

1.47E-02

Avian TLR2B

4

M1A vs. M2A

6.22

4.46E-02

ω = 2.00 (p = 0.11)

ns

M7 vs. M8

9.81

7.43E-03

ω = 1.83 (p = 0.14)

175T, 260V, 496S

M8A vs. M8

6.28

6.09E-03