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Table 1 The enrichment of molecular functions in the urancestral FSF sets

From: The proteomic complexity and rise of the primordial ancestor of diversified life

Urancestor Functional sub-categories (categories) Urancestral FSFs (sample) Extant FSFs (bkgd) Rate for sample Rate for bkgd Ratio P value
min_set Transferases (Metabolism) 6 29 0.066 0.020 4.19 0.0021
  Small molecule binding (General) 4 22 0.057 0.016 3.68 0.021
  Nucleotide m/tr (Metabolism) 7 29 0.100 0.020 4.88 0.00037
max_set Translation (Information) 34 89 0.224 0.063 3.56 E-12
  Nucleotide m/tr (Metabolism) 8 29 0.053 0.020 2.57 0.0083
  1. We evaluated which of 49 sub-categories are enriched by the min_set or the max_set. In the table, sample means the min_set (70 FSFs) or max_set (152 FSFs). The 1,416 FSFs represent the background (bkgd). For convenience, let us assume that M and k represent the number of FSFs that are assigned to a particular sub-category in the background (extant FSFs) and sample (urncestral FSFs) and N and n are the total numbers of FSFs in the background and sample without functional categorizations. The rates for the sample and the background are notated by k/n and M/N, respectively. The ratio was determined by dividing the sample rate by the background rate. The P values were calculated using the hypergeometric distribution. The enrichment of the sub-categories that are listed was supported at the 95% confidence level.