Figure 5
From: Evolution of ligand specificity in vertebrate corticosteroid receptors
Specificity of Daffodil cichlid corticosteroid receptors. Graphs showing relative fold-activation over ethanol for daffodil cichlid (Neolamprologous pulcher) LBD constructs to 10-7 M of ethanol [EtOH], aldosterone [Aldo], and cortisol. MR (A) showed expected sensitivity to cortisol and aldosterone. GR1 (B) was also activated by both aldosterone and cortisol, while GR2 (C) was specific for cortisol, with no aldosterone sensitivity. This pattern of GR aldosterone sensitivity is the reverse, phylogenetically, of what was seen for midshipman GRs (Figures 1, 2 and 3).