Figure 4

Dynamics of the full model (consisting of wild-type cells, cells with resistance on the chromosome, plasmids carrying resistance and plasmids with no resistance) in response to different treatment regimes. "F" denotes wild-type cells, "P" denotes cells infected with a plasmid carrying resistance, "C" denotes cells with resistance on the chromosome, "B" denotes cells infected plasmids which do not carry the resistance gene, and "CP" and "CB" stand for the chromosomally resistant cell types also carrying the respective plasmid. Parameters used are r = 1, a = 1, β = 0.1, s = 0.001, c_c = 0.02, c_p = 0.02, x = 0.05, m = 0.1 and l = 0.5. The dosage is 50 in the top two panels and 5 in the bottom panel, while the treatment interval is τ = 1 in the top panel and τ = 80 in the bottom two panels.