TY - JOUR AU - Cazaux, Benoîte AU - Catalan, Josette AU - Veyrunes, Frédéric AU - Douzery, Emmanuel JP AU - Britton-Davidian, Janice PY - 2011 DA - 2011/05/13 TI - Are ribosomal DNA clusters rearrangement hotspots? A case study in the genus Mus (Rodentia, Muridae) JO - BMC Evolutionary Biology SP - 124 VL - 11 IS - 1 AB - Recent advances in comparative genomics have considerably improved our knowledge of the evolution of mammalian karyotype architecture. One of the breakthroughs was the preferential localization of evolutionary breakpoints in regions enriched in repetitive sequences (segmental duplications, telomeres and centromeres). In this context, we investigated the contribution of ribosomal genes to genome reshuffling since they are generally located in pericentromeric or subtelomeric regions, and form repeat clusters on different chromosomes. The target model was the genus Mus which exhibits a high rate of karyotypic change, a large fraction of which involves centromeres. SN - 1471-2148 UR - https://doi.org/10.1186/1471-2148-11-124 DO - 10.1186/1471-2148-11-124 ID - Cazaux2011 ER -