Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes

Table 6 Conservation of potential substrate-binding residue positions¹

Family	I ²	i+1²	i+4²	Description
CCT1	K	Y	DE	Lys/Tyr/Acidic
CCT2	Q	L	A (GQ)³	Gln/Leu/Ala
CCT3	H	Y	KR	His/Tyr/Basic
CCT4	H	F	K	His/Phe/Lys
CCT5	H	L	Q	His/Leu/Gln
CCT6A	D	A	K	Asp/Ala/Lys
CCT6B	DE	AILMSV	K (R)	Acidic/Medium-Small/Lys
CCT7	Q	Y	D (Y)	Gln/Tyr/Asp
CCT8	H	Y	K	His/Tyr/Lys
CCT8L	DILPT	HLQR	KNRY	Variable/Variable/Polar-Basic
MKKS	Q (H)	FY (H)	DEMQST	Gln/Aromatic/Medium-Small
BBS10	Y (AFQS)	CLY (W)	LMQV	Tyr/Variable/Variable
BBS12	E (KLQ)	KR (HQ)	HNR (ASD)	Glu/Basic/Polar-Basic
Fab1_TCP⁴	D (EN)	I (LMV)	Q	Asp/Ile/Gln

1 Conservation evaluated among sequences in vertebrate genomes. 2 Potential substrate binding positions, corresponding to yeast CCT1 positions 308, 309 and 312 (i = 308) [37]. ³Rare substitutions are listed in parenthesis. ⁴Fab1_TCP domain of vertebrate PIKFYVE orthologs.

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