Table 1 Number of genes of the different subfamilies present in model organism or deduced for key ancestors of current groups from data of multiple species.
From: Animal HECT ubiquitin ligases: evolution and functional implications
Subfamily | Monosiga brevicollis | Ancestor of all animals | Trichoplax adhaerens | Cnidarian ancestor | Ancestor of protostomes, deuterostomes | Caenorhabditis elegans | Homo sapiens |
|---|---|---|---|---|---|---|---|
NEDD4 | 4 | 4 | 4 | 4 | 4 | 3 | 9 (NEDD4, NEDD4L, WWP1, WWP2, ITCH, SMURF1, SMURF2, NEDL2, NEDL1) |
HACE1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
HUWE1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
KIAA0317 | 0 | 1 | 2 | 1 | 1 | 0 | 1 |
UBE3A/E6-AP | 0 | 1 | 1 | 1 | 1 | 0 | 1 |
HECTX | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
HECTD2 | 0 | 1 | 1 | 1 | 1 | 0 | 1 |
Small HERCs | 1 | 1 | 1 | 1 | 1 | 1 | 4 (HERC3, HERC4, HERC5, HERC6) |
UBE3B/3C | 1 | 2 | 2 | 2 | 2 | 2 | 2 (UBE3B, UBE3C) |
TRIP12 | 1 | 1 | 1 | 1 | 1 | 0 | 1 |
HECTD1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
EDD/UBR5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
G2E3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
KIAA0614 | 1 | 1 | 0 | 1 | 1 | 0 | 1 |
HECTD3 | 0 | 1 | 1 | 2 | 1 | 0 | 1 |
Large HERCs | 1 | 2 | 2 | 2 | 2 | 0 | 2 (HERC1, HERC2) |
Not assigned | 4* | 0 | 0 | 0 | 0 | 0 | 0 |
TOTAL | 17 | 19 | 19 | 20 | 19 | 9 | 28 |
No. subfamilies | 10 | 14 | 13 | 14 | 14 | 6 | 15 |