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Figure 2 | BMC Evolutionary Biology

Figure 2

From: Animal HECT ubiquitin ligases: evolution and functional implications

Figure 2

Structures of typical members of the subfamilies. To obtain this figure, all the HECT proteins present in humans, the placozoan Trichoplax adhaerens, the cnidarian Nematostella vectensis and the choanoflagellate Monosiga brevicollis were structurally analyzed using InterProScan [18]. The structures from orthologous proteins in the three animals were generally identical, and therefore all but four of the proteins shown here are from humans. The four exceptions derive from Monosiga brevicollis. Three of them are detailed in the figure. The fourth belongs to the HECTX subfamily, which is not present in vertebrates. Minimal variations were detected in some NEDD4 subfamily proteins (e. g. lack of the C2 domain; lack of one of the WW domains). Also, this figure shows the structure of just one of the Large HERC proteins, HERC1, but does not depict the structure of HERC2 (described before by e. g. [31]).

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