Figure 7
From: Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions
Comparison of linker length between the tCWCH2 sequence motif and general C2H2 ZF. The bars indicate the mean lengths of the linker sequence between C2H2 motifs in the indicated groups. We defined the linker length as the number of amino acids between the last histidine of a ZF and the first cysteine of the C-terminally flanking ZF. The PDOC00028 (general C2H2) alignment contained 12326 sequences and we found 10025 linkers in it. The general C2H2 sequences was further divided into two groups based on the presence or absence of "TGE(K/R)P". The sequence numbers of each group: tCWCH2, 614; general C2H2, 10025; "TGE(K/P)", 4640; "non-TGE(K/R)P", 5385). Error bar, standard deviation. *, P < 1 × 10-100 in Mann-Whitney U-test.