Figure 4

Short-range gene linkage comparisons of the PTH family members in the Takifugu , Xenopus , chicken and human genomes. Genes are represented by closed boxes and the size of the chromosome region analysed is given underneath. Genes were named using HUGO and lines indicate chromosome/scaffold segments. The vertebrate PTH family members are in bold and conserved flanking genes identified within the homologue regions are underlined. The PTH gene is localized in Xenopus scaffold_235 and in chicken chromosome 5 and two conserved genes ARNTL and BTBD10 were identified. The Xenopus and chicken PTHrP maps to scaffold_766 and chromosome 1, respectively and the gene MRPS35 was found in close proximity in all vertebrate regions analysed. PTH-L and SFRS3 genes map to Xenopus scaffold_169 and to chicken chromosome 26. SFRS3 was not linked to Takifugu PTH-L and is present on human chromosome 6 which lacks PTH-L. For simplicity, only genes with correspondence across species are represented. The figure is not drawn to scale.