Skip to main content

Table 3 Degrees and duplicabilities of the genes in the yeast PIN belonging to each functional category

From: Difference in gene duplicability may explain the difference in overall structure of protein-protein interaction networks among eukaryotes

GO biological process category Mean degreea Mean duplicabilitya # of proteins
Lipid metabolic process 2.2 0.79 (---) 127
Cellular respiration 2.2 0.34 57
Vitamin metabolic process 2.6 1.33 (+) 51
Cofactor metabolic process 2.6 0.72 86
Translation 2.6 0.70 167
Aromatic compound metabolic process 2.9 0.50 42
Heterocycle metabolic process 2.9 0.40 48
Carbohydrate metabolic process 3.1 1.80 (+++) 97
Amino acid and derivative metabolic process 3.6 0.81 124
Generation of precursor metabolites and energy 3.9 0.86 95
Sporulation 4.0 0.66 84
Cell wall organization and biogenesis 4.1 1.42 (+++) 129
Response to chemical stimulus 4.1 (+) 1.05 (+++) 271
Protein modification process 4.1 (++) 0.72 368
Cellular homeostasis 4.2 1.12 63
DNA metabolic process 4.5 0.42 (---) 244
Protein catabolic process 4.7 (+) 0.31 (---) 119
Meiosis 4.7 (++) 0.27 (-) 104
Transport 4.8 (+++) 1.93 (+) 649
Response to stress 4.8 (+++) 0.72 348
Organelle organization and biogenesis 4.9 (+++) 0.46 (---) 947
Vesicle-mediated transport 5.3 (+++) 0.56 261
Cell cycle 5.3 (+++) 0.49 292
Pseudohyphal growth 5.4 0.83 50
Signal transduction 5.6 (+++) 1.08 (+) 168
Membrane organization and biogenesis 5.7 (+++) 0.64 149
RNA metabolic process 6.0 (+++) 0.18 (---) 496
Cytokinesis 6.1 (+++) 0.62 91
Transcription 6.3 (+++) 0.22 (---) 178
Conjugation 6.4 (+++) 0.71 89
Anatomical structure morphogenesis 6.8 (+++) 0.63 115
Cell budding 7.5 (+++) 0.78 70
All proteins in the yeast PIN 3.7 0.92 3,891
  1. NOTE. Functional categories containing five or more proteins are shown. Genes in the MIPS database were used.
  2. a. The mean among the proteins contained in each functional category. +++, ++, and + (or ---, --, and -) indicates that a given value is significantly higher (or lower) with P < 0.001, P < 0.01, and P < 0.05, respectively, by the Wilcoxon rank-sum two-sample test with the Bonferroni correction.