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Figure 4 | BMC Evolutionary Biology

Figure 4

From: Mutation accumulation in Tetrahymena

Figure 4

Population mean fitness and variance for both empirical (solid marks) and simulated data (white marks) with bottleneck. Our model simulates the experimental conditions of bottleneck size of one individual, and a mean copy number of 45 for each MAC locus. At each generation copy number varies with probability 1-e-U, and fitness of an individual with z copies was assumed to be W(z) = exp(-s|z-zm|), where s is the selection strength against changes in copy number (z-zm). Simulated data in this figure shows results for s = 0.16, U = 1.5. B shows the log transformation of the mean fitness with the number of bottlenecks. Fit for the rate of decrease was y = -0.0752x + 0.0676; r2 = 0.976 for empirical data and y = -0.0761x + 0.0435, r2 = 0.9763 for the simulated data. Standard errors of the rate of decline were 0.005 and 0.003 respectively, which leads these two regressions not significantly different.

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