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Table 1 AMFE Comparison between non-conserved and conserved pre-miRNAs from human, mouse, and chicken genomes

From: Correlation between sequence conservation and structural thermodynamics of microRNA precursors from human, mouse, and chicken genomes

Species

Conservation

AMFE (kcal/mol)

p 1

p 2

Human

S n (132)

44.1 ± 14.1

  
 

S c 1 (60)

45.2 ± 9.98

5.4×10-1

*3.7×10-3

 

S c 2 (66)

44.6 ± 7.06

7.8×10-1

*8.6×10-9

 

S c 3 (33)

44.7 ± 6.36

7.5×10-1

*2.3×10-6

Mouse

S n (108)

41.0 ± 9.79

  
 

S c 1 (63)

45.1 ± 7.83

*5.2×10-3

*4.5×10-2

 

S c 2 (75)

45.0 ± 6.93

*2.4×10-3

*1.4×10-4

 

S c 3 (39)

43.8 ± 5.89

5.6×10-2

*4.8×10-4

Chickena

S n (21)

42.2 ± 14.7

  
 

S c 2 (40)

41.6 ± 5.59

8.7×10-1

*3.3×10-7

 

S c 3 (19)

42.3 ± 5.05

9.8×10-1

*3.1×10-5

  1. The number of pre-miRNAs within each set is indicated in brackets behind set name. a S c 1 for chicken was excluded as it contained fewer than five pre-miRNAs. AMFE, the AMFE mean values (± SD). Pair-wise comparisons were performed between non-conserved (S n ) and conserved pre-miRNAs (S c 1, S c 2, and S c 3) from human, mouse, and chicken genomes. p1, P-value of two-sample two-sided t-test (without assuming equal variance) for AMFE means. p2, P-value of two-sample two-sided F-test for AMFE variances. * the P-value is significant at the 0.05 FDR level.