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Figure 1 | BMC Evolutionary Biology

Figure 1

From: The synapsin gene family in basal chordates: evolutionary perspectives in metazoans

Figure 1

Genomic organization of the synapsin locus in human and several invertebrate species. The conservation of nested gene organization was really high when different species were compared. In all examined species, the TIMP gene is nested within the intron of Syn gene in reverse orientation, with the exception of Caenorhabditis elegans. Ciona intestinalis and Strongylocentrotus purpuratus are characterized by a peculiar nested organization of SYN-TIMP locus because more than one TIMP sequence was found (two TIMP in C. intestinalis and ten TIMP in S. purpuratus). Alternative transcripts generating by use of different exons are shown for Homo sapiens (isoforms a and b of SYNI, II; isoforms a-f of SYNIII), Branchiostoma floridae (long and short isoforms), Drosophila melanogaster (isoforms a, c and e), C. elegans (isoforms a and b). In particular, for the various transcripts we show with an arrow the start of the transcript, the different exons and only the last exon in common with the isoform having the longer ORF (isoform a for H. sapiens, isoform e for D. melanogaster, isoform b for C. elegans and long isoform for B. floridae). The base-pair length of each coding exon is indicated inside the boxes. The numbers above the colored boxes represent the exon numbering.

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