Figure 3

Analysis of compensatory mutations. Ang protein where all the described functional domains are highlighted in different colors is shown in the middle of the figure, black colored amino acids are sites involved in the active site, blue colored are the ones involved in binding to the nucleus while purple sites are the ones involve in nuclear translocation of the protein. Dark green color shows the binding site while light green highlight the putative binding site. Co-varying sites are shown in a space fill format, and only those sites detected as compensatory are colored in red. (A), (B), (C), (D) and (E) are co-varying sites from group G9, G10, G12, G15 and G16 respectively.