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Table 2 Accelerated evolution of trappin multigenes.

From: Evolution of trappin genes in mammals

Line Region Armadillo Cow Pig Elephant Hyrax Guinea pig
A1 5' flanking region 0.059 ± 0.009
0.115 ± 0.042
0.090 ± 0.008
0.108 ± 0.013
0.010 ± 0.003
0.01 ± 0.003
0.610 ± 0.051
0.850 ± 0.108
0.935 ± 0.039
1.574 ± 0.136
ND
A2 exon 1 (signal peptide) 0.010 ± 0.007
0.016 ± 0.236
0.066 ± 0.026
0.156 ± 1.227
0.078 ± 0.026**
0.286 ± 47.78
0.433 ± 0.099
0.682 ± 0.744
0.708 ± 0.158
2.728 ± 3.455
0.318 ± 0.063
0.588 ± 0.242
A3 intron 1 0.060 ± 0.006
0.163 ± 0.033
0.101 ± 0.009
0.058 ± 0.011
0.017 ± 0.004
0.017 ± 0.004
0.914 ± 0.073
1.326 ± 0.188
0.807 ± 0.046
1.132 ± 0.098
0.397 ± 0.026
0.534 ± 0.034
A4 exon 2 (TGS and WAP) 0.235 ± 0.025**
0.442 ± 0.110
0.167 ± 0.019**
0.299 ± 0.067
0.220 ± 0.022**
0.307 ± 0.040
0.430 ± 0.049
0.577 ± 0.095
0.576 ± 0.066
0.953 ± 0.267
ND***
A5 intron 2 0.045 ± 0.010
0.131 ± 0.280
0.057 ± 0.011
0.094 ± 0.036
0.044 ± 0.008**
0.046 ± 0.008
0.750 ± 0.089
1.083 ± 0.240
0.645 ± 0.081
0.845 ± 0.135
0.403 ± 0.040
0.495 ± 0.066
A6 exon 3 (non coding) 0.077 ± 0.014
0.142 ± 0.095
0.026 ± 0.009
0.032 ± 0.018
0.004 ± 0.004
0.004 ± 0.005
0.420 ± 0.069
0.568 ± 0.161
0.662 ± 0.105
0.990 ± 0.238
0.417 ± 0.052
0.579 ± 0.113
A7 3' flanking region 0.026 ± 0.006
0.045 ± 0.022
0.038 ± 0.006
0.052 ± 0.014
0.016 ± 0.003
0.016 ± 0.003
0.615 ± 0.049
0.815 ± 0.100
0.862 ± 0.034
1.223 ± 0.075
0.363 ± 0.035
0.419 ± 0.050
B1 entire gene except coding region 0.054 ± 0.004
0.079 ± 0.008
0.053 ± 0.003
0.070 ± 0.006
0.019 ± 0.002
0.019 ± 0.002
0.716 ± 0.041
1.092 ± 0.082
1.540 ± 0.024
1.531 ± 0.054
0.376 ± 0.022
0.438 ± 0.032
C1 pre 0.012 ± 0.009
0.022 ± 297.0
0.064 ± 0.022
0.143 ± 1.791
0.071 ± 0.027**
0.097 ± 196000
0.271 ± 0.074
0.344 ± 0.130
0.591 ± 0.141
1.940 ± 5.811
0.318 ± 0.063
0.475 ± 0.671
C2 pre (non synonymous) 0.009 ± 0.009 0.043 ± 0.029 0.059 ± 0.037** 0.226 ± 0.079 0.489 ± 0.152 0.287 ± 0.060
C3 pre (synonymous) 0.020 ± 0.020 0.120 ± 0.058 0.068 ± 0.053** 0.384 ± 0.196 0.942 ± 0.530 0.405 ± 0.155
  dn/ds 0.5 0.4 0.9 0.6 0.5 0.7
D1 TGS 0.118 ± 0.023*
0.213 ± 0.145
0.195 ± 0.031**
0.387 ± 0.229
0.353 ± 0.039**
0.638 ± 0.137
0.604 ± 0.101
0.803 ± 0.214
0.977 ± 0.168
2.166 ± 1.289
0.474 ± 0.038
0.814 ± 0.056
D2 TGS (non synonymous) 0.147 ± 0.036* 0.211 ± 0.046** 0.355 ± 0.056** 0.724 ± 0.165 1.097 ± 0.322 0.452 ± 0.049
D3 TGS (synonymous) 0.057 ± 0.027 0.153 ± 0.056 0.288 ± 0.068** 0.355 ± 0.126 0.726 ± 0.203 0.533 ± 0.086
  dn/ds 2.6 1.4 1.2 2.0 1.5 0.8
E1 WAP 0.309 ± 0.040**
0.364 ± 2.671
0.145 ± 0.028**
0.325 ± 0.037
0.209 ± 0.038**
0.376 ± 0.084
0.337 ± 0.061
0.492 ± 0.171
0.439 ± 0.073
0.702 ± 0.284
0.601 ± 0.087
1.235 ± 1.552
E2 WAP (non synonymous) 0.326 ± 0.067** 0.163 ± 0.044** 0.248 ± 0.051** 0.310 ± 0.093 0.366 ± 0.096 0.609 ± 0.133
E3 WAP (synonymous) 0.315 ± 0.070** 0.091 ± 0.039 0.134 ± 0.060** 0.460 ± 0.152 0.632 ± 0.233 0.733 ± 0.249
  dn/ds 1.0 1.8 1.9 0.7 0.6 0.8
  1. Average JC (upper) and TN (lower) distances of each region among the trappin multigenes for each species (A1--E3) and estimated times of gene duplication (F1--F2) are shown. For each species, the accelerated evolution of each region (A1--A7, C1--E3) was assessed by making comparisons against the average distances of non-coding regions (B2). The bold letters indicate the distances of regions which evolved faster than the non-coding regions of the same genes. * P < 0.05, ** P < 0.01. *** In guinea pig, there is only one trappin gene that has both the TGS and WAP domains. ND, no data; pre, signal peptide (pre-sequence).