Table 1 Classification of all vertebrate tetraspanin LELs
subtype | cysteine pattern of LEL | tetraspanin families |
|---|---|---|
4-cys | CCG--C--C | CD81 |
6-cys-a | CCG--[DN][WY]--PXXCC--C--GC | CD151, CD63, TSPAN3, TSPAN6, TSPAN12, TSPAN18, RDS, UPK1, TSPAN4(the member CD53 secondarily lost cysteine No.4&5) |
6-cys-b1 | CCG--[DN][WY]--[P]XXCXC--C--GC | TSPAN8, some amphioxus and ascidian TSPAN8-like |
6-cys-b2 | CCG--[DN][WY]--PCXC--C--GC | CD37 |
6-cys-c | types other than 6a, 6b1, 6b2 | TSPAN13, some amphioxus TSPAN8-like |
8-cys | CCG--[DN][WY]--C--C--PXXCC--C--GC | TSPAN5, TSPAN10, TSPAN15 and TSPAN33 |