Figure 4From: Inferring nonneutral evolution from contrasting patterns of polymorphisms and divergences in different protein coding regions of enterovirus 71 circulating in Taiwan during 1998-2003Observed (filled box) and simulated (open box) Ka and Ka/Ks values for VP1 (A), 2A (B), and 3C (C), respectively, between enterovirus (EV) 71-B4 and human enterovirus(HEV)-A. Simulated Ks values were set equal to the observations. The proportions of nonsynonymous (N) and synonymous (S) mutations were determined according to the observed N/S ratios in polymorphisms which were 0.10 for VP1, 0.24 and 0.12 for 2A, and 0.21 for 3C (see Table 2 and text for details). The error bar represents 1 standard deviation. p values were determined by 10,000 simulations. * p < 0.05; *** p < 0.001; NS, not significant (p > 0.05).Back to article page