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Table 5 Sites under positive selection detected by the BEB approach in PAML (bold, PP >0.9) and by ConTest (underlined, p < 0.05).

From: Molecular evolution and the role of oxidative stress in the expansion and functional diversification of cytosolic glutathione transferases

Alpha Mu Omega Theta Location Amino acids Experimentally confirmed functional relevance
12     interdomain interface G, A, V, I, T  
36     C-terminal domain interface G, N, Q, K, E, H  
  104    substrate binding pocket A, V, L, I, T, F  
103     substrate binding pocket G, L, M, T, N, E  
   128   substrate binding pocket G, A, L, I, T, R  
111     substrate binding pocket V, L, I, T, F, Y , H Residue 110 [46]
112      I, C, M, T, D, K [46]
  126    interdomain interface G, Q, R, K, E  
  129    substrate binding pocket Q, K, E  
  130     G, A, T, S, Q, E  
  166    substrate binding pocket L, I, M, Q, R  
    186 substrate binding pocket V, L, E, K, R,  
  192    N-terminal domain interface K, E  
    204 substrate binding pocket A, S, K, R, E  
208     substrate binding pocket A, V, L, M, T, D, E, P  
  210    interdomain interface G, A, L, M, S, T, N [30, 47]
212     interdomain interface A, S, N, Q, K, Y Residue 210 [46]
  214    substrate binding pocket V, I, M, T, Q, K, F, H  
    234 C-terminal S, R [48]
  218     I, M, T, N, K, R, E, D  
    237 C-terminal A, L, C, T, D  
  1. Numbering is according to the human sequence of variant 1 for each subfamily.
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