Table 4 Positive selection analysis on mammalian sequences using site models M7 and M8 in PAML [21] (probabilistic models of variable w ratios among sites, the simpler M7 which does not allow sites with w >1 and the more general which does M8).

alpha

all (31)

4.25E-03

**

human (5)

6.61E-04

***

macaque (4)

1.57E-04

***

mouse (5)

4.48E-04

***

rat (4)

5.98E-01

ns

mu

all (33)

5.02E-06

***

human (5)

4.32E-04

***

macaque (4)

4.90E-03

**

mouse (7)

5.36E-01

ns

rat (7)

3.58E-03

**

omega

all (16)

1.00E+00

ns

isoform 1 (8)

1.13E-02

*

isoform 2 (8)

9.21E-01

ns

pi

all (6)

9.87e-01

ns

sigma

all (7)

3.65E-01

ns

theta

all (18)

8.49E-01

ns

isoform 1 (8)

9.85E-01

ns

isoform 2 (6)

3.68E-01

ns

mouse (4)

1.04E-03

**

zeta

all (7)

3.26E-01

ns