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Figure 1 | BMC Evolutionary Biology

Figure 1

From: Molecular evolution and the role of oxidative stress in the expansion and functional diversification of cytosolic glutathione transferases

Figure 1

GSTs structure. A) Active site close-ups showing the different amino acids responsible for activating GSH in different GSTs (left: structures from human GST classes sigma, zeta and omega from top to bottom; right: the amino acids from closely related isoforms (e.g. M1 is GSTM1) are depicted, after superposition of the corresponding structures ); B) Structure of a pi GST dimer; C) Neighbor-joining trees obtained from distance matrices correspondent to the RMSD in angström between C-alpha carbons of representative structures for each cGST class (Table 4 in Additional file 1).

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