Figure 1

Primary structure and specific conserved sequence blocks of Amer proteins. Overall structure of human WTX/AMER1, AMER2 and AMER3 showing the relative position of the conserved blocks (B1 to B6), the APC interacting domains, the nuclear localization signal (NLS), the internal splicing sites (donor and acceptor), the phospholipid binding activity and the β-catenin binding region. Note that B2 partially overlaps with the NLS in human WTX/AMER1. In contrast, only the splicing acceptor is located in a conserved domain (B3). The conserved consensus sequences of domain B1 to B6 are depicted in Figure SM1 B (additional file 1).